A comedy series about Blossom Russo, an astute and witty teenage girl coming of age in a Los Angeles household with her two older brothers and divorced father. Nick, her dad, is a studio musician. Her married brother Anthony is a recovering substance abuser, while her other brother, Joey, is a teenage would-be Lothario. Blossom's best friend is Six who got her name because she was the sixth child in her family. Nick eventually marries Carol, who moves into the Russo home with her young daughter Kennedy; Joey gets signed with a minor-league baseball team; Anthony and wife Shelly have a baby and move away; and Blossom takes up acting.