Janeane Garofalo

Cast in the animated Pixar feature, "Ratatouille"

Co-starred in Richard Kelly's ensemble film, "Southland Tales"

Joined the seventh season of Fox's "24" as a government agent

Joined the cast of the NBC drama "The West Wing," as a media strategist hired by Democratic presidential hopeful Matt Santos (Jimmy Smits)

Starred opposite Martin Short in the comedy "Jiminy Glick in La La Wood"

Co-hosted the Air America Radio's show "The Majority Report," alongside Sam Seder

Starred opposite David Schwimmer in the drama "Duane Hopwood"; screened at Sundance

Cast in the film "Wonderland" based on the brutal murders which involved legendary porn star John Holmes

Starred in "The Laramie Project," (HBO) a true story of an American town in the wake of the murder of Matthew Shepard

Appeared in "Wet Hot American Summer"

Cast as Minnie Mogul in "The Adventures of Rocky and Bullwinkle"

Portrayed Anita Hoffman opposite Vincent D'Onofrio in the biopic "Steal This Movie," about 1960s radical Abbie Hoffman

Appeared as a postal worker with romantic designs on a new co-worker who happens to be a serial killer in "The Minus Man"

Had supporting roles in indie films "Dogma" and "200 Cigarettes"

Played The Bowler in the comic book-inspired "The Mystery Men"

Cast as an FBI agent investigating a serial killer in "Clay Pigeons"

Played an agent opposite Ben Stiller in "Permanent Midnight"

Provided the character voice of Sally on the series "Felicity" (The WB); Garofalo did not take onscreen credit for the role

Debut as feature producer "Sweethearts"; also starred

Delivered a dramatic turn as a deputy in "Cop Land"

Offered fine support as a chain-smoking cynical classmate in "Romy and Michele's High School Reunion"

Starred in the romantic comedy "The Matchmaker"

First feature lead as radio host Abby Barnes in "The Truth About Cats and Dogs"

Memorable cameo appearance, playing a waitress at a medieval-themed restaurant in "The Cable Guy," directed by Ben Stiller

Offered dramatic turn in a two-part episode of NBC's "Law & Order"

Breakthrough screen role as Randy Quaid's 'blind date-from-hell' in "Bye Bye, Love"

Headlined her own "HBO Comedy Half-Hour"

Hosted the stand-up showcase, "Comedy Product" (Comedy Central); also co-produced

Served as special correspondent on Michael Moore's series "TV Nation" (NBC)

Briefly joined the cast of NBC's "Saturday Night Live"

First major film role, "Reality Bites," directed by Stiller; also sang on the soundtrack

Film debut in small role in "Late for Dinner"

TV acting debut, "Passion," an unsold comedy pilot

Relocated to Los Angeles

Spent three years performing in clubs, primarily in Boston and Houston but also on the road

While an undergraduate, began appearing at "open mike" nights at clubs in Boston

Appeared on several TV comedy shows including MTV's "Half Hour Comedy Hour"

Met Ben Stiller

Played the booking agent on "The Larry Sanders Show" (HBO)

Raised in Madison, New Jersey until her last year of high school when she moved to Houston

TV series debut, in the ensemble of "The Ben Stiller Show" (Fox)

Won a cable TV contest to find the funniest person in Rhode Island