Janeane Garofalo

Cast in the animated Pixar feature, Ratatouille

Co-starred in Richard Kelly s ensemble film, Southland Tales

Joined the seventh season of Fox s 24 as a government agent

Joined the cast of the NBC drama The West Wing, as a media strategist hired by Democratic presidential hopeful Matt Santos (Jimmy Smits)

Starred opposite Martin Short in the comedy Jiminy Glick in La La Wood

Co-hosted the Air America Radio s show The Majority Report, alongside Sam Seder

Starred opposite David Schwimmer in the drama Duane Hopwood ; screened at Sundance

Cast in the film Wonderland based on the brutal murders which involved legendary porn star John Holmes

Starred in The Laramie Project, (HBO) a true story of an American town in the wake of the murder of Matthew Shepard

Appeared in Wet Hot American Summer

Cast as Minnie Mogul in The Adventures of Rocky and Bullwinkle

Portrayed Anita Hoffman opposite Vincent D Onofrio in the biopic Steal This Movie, about 1960s radical Abbie Hoffman

Appeared as a postal worker with romantic designs on a new co-worker who happens to be a serial killer in The Minus Man

Had supporting roles in indie films Dogma and 200 Cigarettes

Played The Bowler in the comic book-inspired The Mystery Men

Cast as an FBI agent investigating a serial killer in Clay Pigeons

Played an agent opposite Ben Stiller in Permanent Midnight

Provided the character voice of Sally on the series Felicity (The WB); Garofalo did not take onscreen credit for the role

Debut as feature producer Sweethearts ; also starred

Delivered a dramatic turn as a deputy in Cop Land

Offered fine support as a chain-smoking cynical classmate in Romy and Michele s High School Reunion

Starred in the romantic comedy The Matchmaker

First feature lead as radio host Abby Barnes in The Truth About Cats and Dogs

Memorable cameo appearance, playing a waitress at a medieval-themed restaurant in The Cable Guy, directed by Ben Stiller

Offered dramatic turn in a two-part episode of NBC s Law & Order

Breakthrough screen role as Randy Quaid s blind date-from-hell in Bye Bye, Love

Headlined her own HBO Comedy Half-Hour

Hosted the stand-up showcase, Comedy Product (Comedy Central); also co-produced

Served as special correspondent on Michael Moore s series TV Nation (NBC)

Briefly joined the cast of NBC s Saturday Night Live

First major film role, Reality Bites, directed by Stiller; also sang on the soundtrack

Film debut in small role in Late for Dinner

TV acting debut, Passion, an unsold comedy pilot

Relocated to Los Angeles

Spent three years performing in clubs, primarily in Boston and Houston but also on the road

While an undergraduate, began appearing at open mike nights at clubs in Boston

Appeared on several TV comedy shows including MTV s Half Hour Comedy Hour

Met Ben Stiller

Played the booking agent on The Larry Sanders Show (HBO)

Raised in Madison, New Jersey until her last year of high school when she moved to Houston

TV series debut, in the ensemble of The Ben Stiller Show (Fox)

Won a cable TV contest to find the funniest person in Rhode Island