Mary-Louise Parker

Nominated for the 2009 Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series

Appeared in the off-Broadway play "Dead Man's Cell Phone" at Playwrights Horizons theater

Cast as the mother in the fantasy film "The Spiderwick Chronicles"

Played Jesse's (Brad Pitt) wife, Zee James in "The Assassination of Jesse James by the Coward Robert Ford"

Starred in Oxygen's "The Robber Bride" as Zenia, a glamorous femme fatale; earned an Emmy nomination for Best Actress in a Miniseries or Movie

Cast in John Turturro's big-screen musical "Romance and Cigarettes"; film released theatrically in 2007

Cast in the Showtime series "Weeds" as a suburban mom who beings dealing Marijuana, after her husband's unexpected death; earned SAG (2006, 2007, 2008, 2009), Golden Globe (2007, 2008, 2009) and Emmy (2007, 2008, 2009) nominations for Best Actress in a Comedy Series

Starred in the dark comedy "Saved!" with Jena Malone and Mandy Moore

Starred on Broadway in the revival of Craig Lucas's "Reckless"; received a Tony nomination for her role

Cast as Harper Pitt in the HBO adaptation of "Angels in America"; received a SAG nomination for Best Supporting Actress in a Television Movie or Miniseries (2004)

Had recurring role on the NBC series "The West Wing"; reprised her role as women's-rights advocate Amy Gardner for the shows final episodes in 2006; received an Emmy (2002) nomination for Best Supporting Actress in a Drama and a SAG (2003) nomination for Best Ensemble

Portrayed Molly Graham in the thriller feature "Red Dragon" the prequel to "Silence of the Lambs"

Garnered rave reviews for performance in the Off-Broadway play "Proof"; production moved to Broadway in the fall

Played an unhappy young woman who finds purpose in a new romance in the Hallmark Hall of Fame presentation "Cupid & Cate" (CBS)

Co-starred in the Slamdance-screened "Let the Devil Wear Black"; a modern interpretation of Shakespeare's Hamlet written and directed by Stacey Title

Portrayed a cake maker who problematically lacks a sense of taste in the Canadian-made "The Five Senses"

Appeared in small but pivotal role as the free-spirited (and later suicidal) Lucy in the Hallmark Hall of Fame presentation of "Anne Tyler's 'Saint Maybe'" (CBS)

Returned to the NYC stage in the Off-Broadway production of Alan Ayckbourn's "Communicating Doors"

Earned critical acclaim for her performance of a young girl molested by a relative in the Pulitzer Prize-winning play "How I Learned to Drive"; played character at various ages from teens to adulthood

Acted the part of Henrietta Stackpole in Jane Campion's "The Portrait of a Lady"; based on the novel by Henry James

Delivered a poignant portrayal of a woman dying from AIDS in "Boys on the Side"

Portrayed a parapalegic deaf mute in the feature "Reckless"; film is based on the play by Craig Lucas

Starred opposite John Turturro as singer Phyllis McGuire in HBO's "Sugartime"

First appearance in a Hallmark Hall of Fame production, "A Place for Annie" (ABC) as a surly AIDS patient who tries to get back the baby she abandoned

Played John Cusack's girlfriend in Woody Allen's "Bullets Over Broadway"

Acted Off-Broadway in John Patrick Shanley's Hollywood satire "Four Dogs and a Bone"

First starring role in a feature, "Fried Green Tomatoes"

Portrayed Dee, a secretary and part-time lover of Kevin Kline, in Lawrence Kasdan's "Grand Canyon"

Broadway debut in Craig Lucas' "Prelude to a Kiss" (originated the role at the Berkeley Repertory Theatre and appeared in off-Broadway production at the Circle Rep); earned a Tony nomination as Actress in a Play

Played a neighbor helping her gay friend through the early years of the AIDS crisis in Norman Rene's "Longtime Companion"

Film debut, "Signs of Life"

Off-Broadway debut, "The Art of Success"

TV-movie debut, "Too Young the Hero" (CBS)

Off-off-Broadway debut, "The Girl in Pink" at the Quaigh Theatre

Played a recurring role in the ABC daytime drama "Ryan's Hope"

Appeared in regional theater productions of "The Night of the Iguana" and "The Little Foxes"

Grew up in Arizona, Tennessee, Texas, Thailand, Germany and France where her father served in the US Army

Will star in the Broadway revival of Henrik Ibsen's "Hedda Gabler" (2009)