Carla Gugino

Played a discredited astrophysicist, opposite Dwayne Johnson in "Race to Witch Mountain"

Portrayed Sally Jupiter, the original Silk Spectre, in the film adaptation of "Watchmen"

Starred in Chicago's Goodman Theater production of Eugene O'Neill's "Desire Under the Elms"

Appeared opposite Robert De Niro and Al Pacino in the Jon Avnet-directed, "Righteous Kill"

Joined the fourth season of the HBO series, "Entourage" playing Vince's new agent

Played Russell Crowe's estranged wife in Ridley Scott's "American Gangster"

Cast opposite Ben Stiller in the action-adventure-comedy, "Night at the Museum"

Cast as a parole officer in Frank Miller's noir thriller, "Sin City"; co-directed by Miller and Robert Rodriguez

Appeared on Broadway in Arthur Miller's "After the Fall" as the naive, doomed sexpot based on Miller's ex-wife Marilyn Monroe

Cast as the titled character in the drama series "Karen Sisco" (ABC)

Rejoined the "Spy Kids" crew for the trilogy, "Spy Kids 3D: Game Over"

Co-starred with and directed by Frank Whaley in "The Jimmy Show"

Reunited with Banderas for "Spy Kids 2: The Island of Lost Dream"

Co-starred with Antonio Banderas as a married couple who happen to be retired spies in "Spy Kids"

Played the wife of Jet Li in the action film, "The One"

Headlined the Hallmark Hall of Fame production, "A Season for Miracles" (CBS)

Joined the cast of "Chicago Hope" (CBS) as Dr. Gina Simon

Cast opposite Nicolas Cage in "Snake Eyes"

Produced and co-starred in "Judas Kiss" (aired on Cinemax in USA in lieu of a theatrical release before its debut on video)

Acted in the fantasy feature, "Michael"

Played Ashley Schaeffer in the first season of "Spin City" (ABC); left after several episodes, when show was revamped

Played Sarah Jessica Parker's unhappily married younger sister in the comedy, "Miami Rhapsody"

First lead role in a feature film, "Son-in-Law"

TV-movie debut, "Murder Without Motive" (NBC)

Film debut in "Troop Beverly Hills"

Was a regular on the CBS primetime serial "Falcoln Crest"

Began modeling at age 15

Moved to California with mother at age six

Spent part of her childhood living in a teepee in Northern California with her mom