Taking notice of the American Pharmaceutical slogan, "Does Your Soul Have a Cold? (Kokoro no Kaze)," being advertised Japan, Mike Mills explores how the country deals with depression from the perspectives of Japanese people taking anti-depressants. Citing the quintupling of antidepressant sales in Japan from 1998 to 2003, documentary chronicles a nation still coming to terms with how depression is affecting its citizens and how American interests and influence are shaping this change.