Don Cheadle

Co-starred in "Hotel for Dogs," a film adaptation of the Lois Duncan novel of the same name

Portrayed Ralph "Petey" Greene, a real-life ex-con-turned-radio and TV host in "Talk to Me"; earned an Independent Spirit Award Nomination for Best Actor

Re-teamed with the original cast for "Ocean's 13"

Produced and starred in Paul Haggis' directorial debut "Crash," a multicharacter study of L.A. race relations; earned a SAG nomination for Best Supporting Actor

Cast opposite Naomi Watts, Sean Penn and Jack Thompson in "The Assassination of Richard Nixon"

Portrayed Paul Rusesabagina, a hotel manager who housed over a thousand Tutsis refugees during their struggle against the Hutu militia in Terry George's "Hotel Rwanda"; received a Golden Globe, SAG and an Oscar nomination for Best Actor

Reunited with original cast for "Ocean's Twelve" again directed by Steven Soderbergh

Received grammy nomination for Best Spoken Word Album for "Fear Itself"

Had a recurring role on the NBC drama "ER" as Paul Nathan, a med student who suffers from Parkinson's disease; received an Emmy nomination for Outstanding Guest Actor in a Drama Series (2003)

Acted opposite Jeffery Wright in Suzan-Lori Parks' Off-Broadway drama, "Topdog/Underdog"; was unable to recreate role on Broadway in 2002 due to scheduling conflicts

Again collaborated with Clooney and Soderbergh for the "Ocean's Eleven" remake

Portrayed the manager-lover of a troubled rock singer in "Things Behind the Sun"; screened at Sundance

Reteamed with Soderbergh to play a DEA agent in "Traffic"

Wrote and directed the digital film "The Jesse Borr Story" (lensed 2000)

Had lead in the HBO adaptation of "A Lesson Before Dying"; received Emmy nomination

Cast as Sammy Davis Jr in the HBO movie "The Rat Pack"; received Emmy nomination

Had featured role of L.D., a moralist gang leader, in "Bulworth"

Played Snoopy, a psychopathic killer in Steven Soderbergh's "Out of Sight," co- starring George Clooney

Appeared as porn star Buck Swope in "Boogie Nights"

Co-starred in John Singleton's underrated "Rosewood," as a piano teacher who stands up to racists

Breakthrough role as Mouse, the psychopathic sidekick to Denzel Washington's Easy Rawlings in "Devil in a Blue Dress"

Played district attorney Jonathan Littleton on the CBS drama series "Picket Fences"

Played recurring role of Bennie on "Hangin' With Mr. Cooper" (ABC)

TV series debut as the overly competent hotel manager in "The Golden Palace," the CBS spin-off of "The Golden Girls"

Starred and co-wrote the theme for the unsold NBC comedy pilot "In the House"

Played pivotal role of Rocket, a murderous gang member, in the drama "Colors"

TV debut, guest shot on "Hill Street Blues" (NBC)

Feature film debut, "Moving Violations"

Acted with the Guthrie Theatre in Minneapolis, Minnesota and with the New York Shakespeare Festival in NYC's Central Park

Born in Kansas City, Missouri

Had first acting role in a fifth grade production of "Charlotte's Web"; cast as the rat Templeton

Raised in Lincoln, Nebraska and Denver, Colorado

Replaced Terrence Howard as Jim Rhodes, best friend to Downey's Tony Stark in the sequel to "Iron Man" (due out in summer 2010)