When Isaac, a favorite hospital lab tech, discovers an inoperable tumor wrapped around his spine, he turns to Dr. Derek Shepherd to do the impossible. Derek then tests the Chief's authority when Richard objects to moving forward with the risky surgery.
As Thanksgiving, Christmas and New Year's pass, Miranda's father, William, who disapproves of her choices in life visits Miranda. Meanwhile, Mark and Lexie must cope with the shocking arrival of a woman from his past, and Thatcher Grey questions the Chief's recent behavior as Meredith comes to his defense.
The hospital staff is left to deal with the aftermath of George's passing in the first part of the two-part season premiere. Hitting the staff hard, they all find unique ways to get through the various stages of grief. George's mom returns, faced with the difficult task of deciding what to do with his organs.
In the second half of the season premiere, time has passed and everyone is struggling after losing George. Meredith and Derek seem to be consummating their marriage anywhere and everywhere, while Dr. Wyatt instructs Cristina and Owen to abstain from sex. Meanwhile, the Chief is mysterious about what's going on at the hospital. Arizona enlists Callie's help with a difficult to diagnose patient and Lexy tries to hel…more
Members of the hospital staff find unique ways to deal with their grief at George s death; George s mother faces the daunting task of deciding what to do with his organs.
Several weeks after her near-death experience, a recovering Izzie returns to work. Meanwhile, nervous that there will be layoffs in the hospital in the wake of an announcement from the Chief, the Seattle Grace residents compete to survive the cuts, including Cristina, who attempts to work alongside Arizona in pediatrics. Bailey and Alex's patient's already complex case is further complicated by her schizophrenic s…more
When Meredith and Lexie's father, Thatcher, returns to the hospital with a failed liver, it is up to Meredith to save his life. Meanwhile, Izzie empathizes with a patient riddled with tumors, as Mark, annoyed with Cristina's competitive zeal, tricks her into assisting on an unusual surgery.
The residents of Seattle Grace and Mercy West vie for surgeries and their careers as day one of the hospital merger begins. Meanwhile, Arizona stands by an enraged Callie when her father, Mr. Torres, employs a priest to help convince her to date men, and Izzie experiences the brunt of her new surgical competition.
After a burn victim unexpectedly dies in the midst of a chaotic ER, the Chief and board member Jennings interrogate the residents to find the culprit, as all the Mercy West and Seattle Grace residents defend their actions in an effort to save their jobs.
A generous donation is offered to Seattle Grace by the parents of Arizona's 10-year-old patient. However, when his condition worsens, she finds herself in a conflict of interests. Meanwhile, Cristina tests her boundaries with Owen at the hospital, and adding insult to injury, Alex is left with all of Izzie's hospital bills to contend with.
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