Dr. Addison Forbes Montgomery's struggles at Seattle Grace and her search for happiness in Los Angeles; a music video set to Mat Kearney's ``Breathe In Breathe Out''; a preview of the season.
Having just returned from her honeymoon with Meredith, Cristina searches for Burke, but he's nowhere to be found. Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns. Among the interns are George, repeating his intern year after failing his exams, and Lexie Grey, Meredith's half-sister whom she has never met. Now that Derek's relationship with Meredith has reached an emo…more
The residents and interns treat the victims of a massive explosion at an apartment building. Alex investigates the cause of the accident. Mama Burke returns to collect her son's things just as Cristina trades her wedding presents in exchange for surgeries. Lexie tries to have a heart-to-heart with an unwilling Meredith. While Callie is overwhelmed with her duties as Chief Resident, Bailey searches for an outlet for her p…more
The new interns are dazzled by the skill level of fellow intern George, while Lexie helps keep his "repeater" status a secret. Meredith half-heartedly helps Lexie with her first emergency patient. Sloan and Richard attempt a radical new surgery to save a woman's ability to speak. George is compelled to tell Callie of his past indiscretion with Izzie. Really Old Guy awakes from his coma and wants to die.
The Chief's wife, Adele, rushes their niece to Seattle Grace, the hospital where she once had her prom. Izzie reveals her feelings for George to a mutual friend, and the reaction is not what she expects. Derek teaches Cristina how to be a better teaching resident. The world's oldest living intern, Norman, misdiagnoses one of Meredith's patients.
It's Halloween, and the day is full of surprises for the doctors of Seattle Grace. Alex receives an unexpected and welcome visit from his former patient, Ava/Rebecca. Unfortunately, his intern Norman has a stroke while he is spending alone time with her. Meredith is convinced that her mother's ashes are haunting her, so she brings them to the hospital. Cristina is snubbed by the new head of thoracic surgery, Dr. Erica …more
With his marriage in turmoil, the Chief turns to his fellow male surgeons for a "gentleman's evening." Cristina and Izzie heatedly compete for the same cardio surgeries and the favor of Dr. Hahn. George and Izzie plan to have their "first real night" together. Callie and Sloan decide to try and embarrass George by giving him a humiliating job. Meredith treats a skydiver who fell 12,000 feet when his parachute didn't op…more
George and Izzie worry that they don't have any romantic chemistry. Derek asks for more than a physical connection from Meredith. Much to his own surprise, Mark develops a crush on a Erica Hahn. Erica refuses to let Cristina in on her surgeries. Callie's role as Chief Resident is placed in jeopardy after she delegates much of her job to Bailey. Richard walks in on Derek and Meredith having sex. Lexi continues to try …more
A school bus crash floods Seattle Grace with teenagers, reminding everyone of their high school days. Miranda struggles with her self worth when a friend from high school comes to the hospital. Derek goes out on a date with Sydney Herron. Meredith sees her father for the first time since her stepmother's death when he shows up drunk at the hospital. Rumors fly about Izzie and George's relationship.
An ambulance crash endangers the lives of the paramedics involved. As Meredith and the Chief work on-site to save them, Bailey treats a patient who refuses her help because of her race. Ava returns for Alex and meets his other girlfriend in the process.
Meredith furiously works to save the life of a paramedic trapped inside an ambulance, as her sister, Lexie, holds the life of a patient in her hands. Derek must rely on the help of a nurse to save a patient's life, as Bailey struggles to balance her personal life with her work.
Bailey's family faces a medical trauma, just as her marriage is falling apart. A surprise visit from George's mother comes as a shock to both Izzie and Callie. A faith healer challenges Erica and Alex's beliefs in traditional medicine. Derek must deal with the aftermath of his kiss with Rose.
Six weeks after Derek and Meredith ended their relationship, Meredith, Alex, Izzie and Cristina compete in a surgical contest, with Bailey serving as judge; George and Lexie adjust to their new, squalid apartment; Callie finds a friend in Erica.
Addison returns to Seattle Grace to perform an operation and is taken aback by all of the changes in her old co-workers' lives. Meredith and Derek's clinical trial has its first patient. Rebecca/Ava returns with shocking news for Alex - she's pregnant. Callie worries that Erica might be a lesbian and might be interested in her.
The nurses' objections to McSteamy's trysts lead to the instating of a new "date and tell" policy. News of Burke's latest career achievements force Cristina to face her feelings for her ex. Meredith and Derek admit a veteran soldier into their clinical trial. Callie turns to Sloan in her time of need.
Dr. Wyatt refuses to let Meredith give up on therapy, Alex learns the truth about Rebecca's medical condition, the Chief insists that Erica perform a risky surgery on his mentor, and after receiving news of Burke, Cristina continues to do things contrary to her nature, going so far as cleaning her always-messy apartment.
Meredith and Derek get one last shot at success in their clinical trial; the surgeons work together to free a boy from a block of cement; Izzie helps Alex care for Rebecca; Lexie uncovers critical information about George's status as an intern.
Izzie helps Alex care for an ailing Rebecca, and Lexie discovers critical information about George's intern status.
Meredith and Derek have one last shot at a successful outcome in their clinical trial, as the other surgeons work together to free a boy from a hardening block of cement.
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