House is brought in for a consult on a Death Row inmate with mysterious symptoms. Cameron feels the the hospitals resources would be better served elsewhere, with a young cancer patient. House and Stacy try to establish a good work relationship, especially after he lies to her to secure the transfer of the inmate to the hospital.
A 9-year-old terminal cancer patient is brought before House after she experiences hallucinations. House figures out a way to help her, but it will involve serious risk. The young patient asks Chase if he will kiss her because she's never kissed a boy. They discover that she has a tumor on her heart, but when it's benign, they believe that a clot may be navigating her body.
Cuddy feels responsible when her handyman falls off her roof and starts to show weird signs. House's team amputates one hand to prevent the spread of infection, but then the other starts to show signs and they have to seek out the source before it kills the patient.
A famous doctor known for his humanitarian TB efforts in Africa collapses and comes under House's care but refuses to take treatment until his cause gets the proper media exposure. House believes his symptoms are more than just TB.
A college graduate falls ill at a graduation party, suffering through shocks. House and team try to discern the cause of the mysterious ailment. House tries to avoid a dinner with his own parents.
A professional cyclist arrives at the clinic and admits to using performance enhancing substances. Cameron debates whether the media should be informed of this. House tries to come between Mark and Stacy.
House is confronted by a gay man, Kalvin, with AIDS who demands treatment. The patient coughs blood onto Cameron who then must be checked for the virus herself. Kalvin's father begins to show signs of illness. House makes moves on Stacy using sensitive information he got about her relationship with Mark.
A lawsuit is brought against Chase and House for the death of a mother who came in with stomach pains. A disciplinary committee convenes to determine whether either of them is at fault in the death. They put another doctor in charge of House, Dr. Foreman.
A horse gambler collapses in front of House while at an Off Track Betting site and House must contend with Foreman being in charge.
A journalist with a head injury is sent to the hospital when he can't make coherent statements and the team must figure out his problem with House out of town.
Cameron worries about the potential results of her HIV test. House basks in the afterglow of his kiss with Stacy, but Wilson tries to keep a level head about things. House must dig through the life and lies of a busy housewife to find the true reason why she's shown signs of degenerating physically and mentally.
A teenager tragically burned in an accident shows mysterious heart symptoms and House and team are called in to figure out why. Unfortunately, standard procedures are out of the question because of his condition. House brings a colleague to the hospital to speak on one of his published works so that House can call it into question. As it turns out, the same doctor got House kicked out of medical school for cheating. H…more
House treats a teenage supermodel who gets into a catfight on the catwalk and then passes out. When her tox-screen shows heroin, she's treated for addiction. Unfortunately, her symptoms continue after she's weened off the drugs. It turns out that she's actually a "he" with undescended testes. House fights off increasingly bad leg pains. Cuddy helps him with what she later confesses was a placebo…more
House takes up the case of a man who had a silent seizure. After discovering that he is in need of a heart transplant, the team attempts to use the heart of a recently deceased patient, but first must determine what killed her to ascertain the organ's viability.
House attempts to prove that a woman is secretly killing her husband. Meanwhile, Wilson splits from his wife, only to take up in House's house, and begins to handle all the cooking duties.
House treats a girl taking a serious heart medication, whose boyfriend triggers an allergic reaction upon his arrival which throws her immune system out of whack. Meanwhile, House and Wilson continue to have an uneasy relationship as new roommates.
The hospital is hosting an oncology benefit, when a 6-year-old boy is brought in exhibiting symptoms that aren't too unusual, especially since a patient recently passed away from similar illness. House is convinced the boy's case is identical and that he can predict the course of the young patient's illness. Relying on Wilson to keep Cuddy at the poker table so she doesn't interfere on this one, House beco…more
A young woman’s health becomes a question of ethics. Hannah has been unable to sleep for sometime now. It isn't until Dr. House discovers she will need a liver transplant that he also uncovers some vital information about her and her partner Max, which might lead to her death. Foreman is being accused of theft. Cameron believes she has been the victim of a literary robbery when Foreman’s article starts to seem fre…more
House wants to call a 15-year old faith-healer's bluff, but when the boy is admitted into the hospital, he touches a cancer patient and causes the cancer to go into remission; House must question his own faith. After being diagnosed, the boy refuses brain surgery, but when his condition worsens, House and his staff have to make a decision. Meanwhile, Cameron is still sour about Foreman stealing her idea, or so she say…more
A police officer in critical condition has bizarre symptoms; Dr. Foreman finds himself in an unpleasant situation.
The police officer that had the same symptoms as Foreman has died. Fearful of his own death, Foreman contacts his father who rushes to be by his son’s side. Meanwhile, house and the gang are still trying to do everything they can to help Foreman, including infecting him with another disease, but when that doesn't help, an extremely dangerous brain biopsy may be the only way of finding out the cause. It all comes dow…more
An injured police officer with an uncontrollable laughter has house baffled; but when Foreman starts showing symptoms and the officer's condition turns fatal, House must find the cause in time to save Foreman's life.
A young mother has a seizure while bathing her newborn son and nearly drowns him. House and the team have two cases at one time as they try to save the infant and determine the cause of the mother's seizures.
A 16-year-old Hurricane Katrina victim suffering from hallucinations as a result of the tragedy is brought to House by his former bandmate who recently found out the girl is his daughter. Although House fears his friend is being scammed, he takes the case. As he works his way through the girl's lies so he can diagnose and treat her, he's forced to tell a few lies of his own.
As House and his team are working on the diagnosis of a man with a giant, swollen tongue, the husband of a former patient walks into House's office and shoots him. House continues to treat his patient from his ICU hospital bed with the shooter, who has been shot by hospital security and hand-cuffed to his bed, as his roommate. When the after-effects of the shooting begin to impact House, he starts to question his own …more
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