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A 22-year-old man who had just called out sick from work loses consciousness after having sex with his fiancée. So he really is sick, but with what?

House sees two infants in the neonatal ICU and determines immediately that an infection is spreading through the hospital. He s right, of course, but what caused it? House s approach is Solomonic, in a way.

Something poisoned a high-school student who became ill during a calculus exam, and House and his team must figure out what it was, while battling the young man s mother, who doesn t trust any of them.

A jazz musician (Harry Lennix), who s already paralyzed from the waist down, collapses at a recording session (which features a cameo by Brandy).

A 16-year-old suffers respiratory arrest while making out with his girlfriend. The doctors can t figure out what s wrong and, making matters worse, his Gypsy parents instinctively distrust the doctors.

A 16-year-old car-crash victim is insensitive to pain. She s also very headstrong, and concerned about her mother, who was injured more seriously in the crash. Perhaps not surprisingly, House takes a particular interest in the girl.

Dave Matthews guest stars as a 35-year-old savant whose hand constricts during a piano recital. As the patient s condition quickly deteriorates at the hospital, House makes plans (unannounced, of course) to go to Boston.

A struggling artist (Breckin Meyer) taking part in three drug trials to pay his bills is also suffering from something that s altering his perception and threatening not only his livelihood but his life as well.

A pain-free House is on the run. Literally. After eight weeks of rehab from the shooting, he s running to the hospital, where two patients await him. One is a mute quadriplegic (the result of brain cancer) who drove his wheelchair into a pool.

A 7-year-old boy plunges from his bedroom window after telling his parents (not for the first time) that aliens were after him. He also has unexplained bleeding and complains about a metal chip in his neck.

A noted 71-year-old cancer researcher (Joel Grey) collapses in his lab. The problem could be with his heart or his lungs; House and his staff don t know. But the researcher knows that he doesn t want them to find out. He just wants to die.

A 16-year-old boy starts bleeding just before the car crash that lands him in the hospital, and the symptoms add up to nothing but a likely death. Meanwhile, Cuddy suggests an unorthodox approach to get House off his painkillers. He takes her up on it.

A major-league pitcher with a history of drug abuse (Scott Foley) develops brittle bones. Steroids could be the cause, but he insists he s clean, and tests back him up. He doesn t appear to have cancer, either.

Cuddy assigns House to treat an Iraq vet complaining of Gulf War syndrome who happens to be a nephew of a big hospital donor. House recognizes the patient s face---from a nightmare he had the night before.

A pregnant 42-year-old celebrity photographer (Anne Ramsay) suffers a stroke while shooting a rock star (All-American Rejects Tyson Ritter), and soon her kidneys and liver begin to fail as well.

House and Cuddy have an airborne medical crisis while returning from a symposium in Singapore. It begins when a first-class passenger becomes violently ill. House suspects meningitis, and soon others become sick, Cuddy among them.

He has little patience for patients, but misanthropic Gregory House is a brilliant diagnostician who probes life-and-death medical mysteries while CSI -style graphics follow each disease s progression.