Shelley Panborn's first day introduces to her disparate staff who don;t always work well together. Meanwhile the new intern Maggie Yang is pulled into an a procedure that Dalgety and Kellerman made look like an autopsy so they could do a biopsy without alerting the admistration that their patient has no insurance.
Doctors at Mission General Hospital in San Francisco bend the rules and exploit loopholes to treat their patients.
A camera crew creates an obstacle for Maggie to deal with and in an effort to work around the system, Kellerman steals a heart machine to save a patient.
A car crashes through a bustop in front of the hospital, flooding them with injured and a superstitious Kellerman has trouble operating on a Buddhist dignitary.
Dr. Wiseman flies Kellerman and Dalgety in bad weather to Las Vegas to deliver a heart to a transplant patient but the flight may be more dangerous than the surgery. Also, Donge has the hots for Poole and Maggie is the victim of sexual harassment from Dr. Posner.
When Donge comes up with a plan for a "virtual," e-mail only doctor, Dalgety, with a little help from Maggie, attempts to undermine it. Also, a patient and a death row prisoner both need the same heart transplanted to survive.
On Halloween, Maggie discovers the shocking history of a string of murders at the hospital years before. And one of the hopspital administrators suffers embarrassment when he and a friend are arrested in drag for fighting with some college kids over a parking space.
A patient who has wings growing out of his back can also seemingly heal the sick; Maggie tries to help a blues singer get treatment for a chronic cough that turns out to be more than she suspected; Poole blames Kellerman when she catches a patient smoking pot and Kellerman desperately tries to save a volunteer who has been shot in a robbery.
Dalgety is frustrated with a patient who refuses surgery because he thinks he is an alien from outer space; Donge is hospitalized for a heart problem as he tries to take over as the Cheif Adminstrator; and Kellerman's ex-wife announces she is pregnant.
Dr. Joyner helps an abandoned newborn in need of heart surgery; Kellerman performs surgery alongside an ex-lover; a homeless man is stabbed in the waiting room.
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