Melissa McCarthy

Cast in a supporting role alongside Christina Applegate on the ABC sitcom, "Samantha Who?"

Played a leading role in the John August-directed, "The Nines" with Hope Davis and Ryan Reynolds

Writing and directing debut, the short film "Polk Valley"; also played the main character

Had a small role in "The Life of David Gale"

Played Ben Affleck's office buddy in the romantic comedy, "The Third Wheel"

Appeared in "The Kid" starring Bruce Willis

Series debut as a regular, playing Lorelai's best friend Sookie in the WB series, "Gilmore Girls"

Had a small role in Doug Liman's ensemble feature, "Go"

Starred in John August's independent short film, "God"

First appearance on TV, a bit part on her cousin's MTV sketch comedy show, "The Jenny McCarthy Show"

Became a member of the Los Angeles-based Groundlings improvisational comedy troupe

First performed stand up in New York at The Improv and Stand Up New York

Will star with Missi Pyle and Allison Janney in "Pretty Ugly People" (lensed 2008)