You might see a person in a wheelchair and assume that they are weak. But make that assumption about the wrong person, and you could be in a world of trouble. Just like in real life, there are plenty of wheelchair-bound people who are actually total badasses. Whether they are good guys or villains, whatever you do, don't underestimate these TV characters.
Hector Salamanca, "Breaking Bad"
Yes, he's in a wheelchair. And yes, he's mute, and can only communicate by ringing a bell. But with Walter's help, Hector becomes a suicide bomber and takes down Gus Fring and his associate Tyrus. And let's not forget his long reign as a major player in the cartel and as head of the Salamanca family.
Logan Cale, "Dark Angel"
Logan Cale was paralyzed from the waist down after being shot in the spine, but that doesn't mean he's helpless. In one great scene, an attacker comes after Logan, and the two tussle on the ground. Logan reminds his attacker, "The thing about wheelchairs: they build upper-body strength," and proceeds to beat up the man who came after him with great success.
Dr. Hawkins, "M.A.N.T.I.S."
Speaking of short-lived Fox programs, "M.A.N.T.I.S." chronicled the life of a paraplegic inventor who developed an exoskeleton that allowed him to have super strength and fight criminals. Oh, and in case you were wondering, the acronym in the show's title stands for Mechanically Augmented Neuro Transmitter Interception System.
John Locke, "Lost"
Two words: John Locke. Wheelchair-bound after an eight story fall, he decides to go on a walkabout in Australia. When he is denied the chance, he heads home on the fated flight. After the crash, he magically has the ability to walk again, and becomes one of the most valued members of the Island community.
Davros, "Doctor Who"
Davros doesn't sit in a wheelchair, per se. It's more of a life-support chair, a Darth Vader-like scooter he's mounted in from the waist down. Despite only have one good eye and one functioning hand, you don't want to mess with him. Creator of one of the most feared races in the universe, the murderous Daleks, Davros is one of the Doctor's most feared and notorious enemies.
Walter Sykes, "Warehouse 13"
Turned evil by an artifact that gave him the power to walk, this wheelchair-bound villain wants revenge against the agents of the warehouse for taking his miraculous artifact. The artifact also caused a personality change, making him extremely dangerous.
Lex Luthor, "Smallville"
By the time Season 8 rolls around, Lex is pretty well incapacitated thanks to his injuries in the previous season's finale episode. Unable to move or breath, missing an eye, and hooked up to a life-support system in the back of a moving truck, he's more disabled than most of the others on this list. And yet, he's still among the most dangerous.