The Arrested Development and Better Off Ted alum will play the role of the vampire matriarch made famous by Yvonne De Carlo in the 1960s series. True Blood alum Mariana Klaveno was slated for the role, but could not be released from her contract on Marc Cherry's Devious Maids pilot, which failed to garner a pickup at ABC but is reportedly being shopped at Lifetime. De Rossi most recently starred in The Smart One, a comedy pilot that ABC also passed on this development season.
The 39-year-old actress will star alongside Jerry O'Connell, who plays her husband Herman Munster, Eddie Izzard as the quick-witted grandpa and Charity Wakefield as the family's "plain" cousin Marilyn. Mason Cook will play Herman's werewolf son Eddie.
Mason Cook cast as Eddie in NBC's Munsters reboot
The re-imagining of the 1960s series, created by Pushing Daisies' Bryan Fuller and directed by Bryan Singer, will maintain the core elements of the original series, although it will now be an hour-long drama.
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