Parker Posey

Played a single mom thrown into a world of international espionage in "Fay Grim," Hal Hartley's sequel to his 1997 film "Henry Fool"

Starred in Zoe Cassavetes' directorial debut, "Broken English"; earned an Independent Spirit Award Nomination for Best Actress

Cast as Kitty Koslowski, Lex Luthor's villainous henchwoman in Bryan Singer's "Superman Returns"

Reunited with Guest to play an actress in "For Your Consideration"

Played a woman divorcing her rock star husband (Michael Sheen) in the romantic comedy "The Laws of Attraction"

Played ruthless villain Danica Talos in "Blade: Trinity"

Starred in the Independent feature "The Event"

Appeared with Carmen Diaz in "The Sweetest Thing"

Co-starred in "Hell on Heels: The Battle of Mary Kay"; received a Golden Globe nomination for Best Supporting Actress

Co-starred with Kyra Sedgwick and Fairuza Balk in Rebecca Miller's "Personal Velocity"; earned an Independent Spirit Award Nomination for Best Actress

Starred as an assistant D.A. uncovering an AIDS-related mystery in "The Event"

Appeared in teen flick "Josie and the Pussycats"

Played a neurotic wife in "The Anniversary Party"

Broadway debut opposite Matthew Broderick in the Elaine May comedy "Taller Than a Dwarf"

Featured in Christopher Guest's award-winning comedy "Best in Show"

Gave memorable comedic performance in "Scream 3"

Cast in first major feature role supporting Tom Hanks and Meg Ryan in "You've Got Mail"

Appeared in critically acclaimed feature "Henry Fool" (won Best Screenwriting Award at Cannes)

Earned acclaim for performance as Jackie-O in "The House of Yes"

Starred in "Clockwatchters" with Lisa Kudrow and Toni Collette

Starred in the award-winning independent film "The Daytrippers" (premiered at Toronto Film Festival)

Starred in the seminal Christopher Best comedy "Waiting for Guffman"

First feature in a starring role, "Party Girl"

TV miniseries debut, "Armistead Maupin's Tales of the City" (PBS)

Feature acting debut, "Joey Braker"; also appeared in two other films that year

TV debut in a regular role, "As the World Turns"

Co-starred with Jessica Alba in the supernatural thriller, "The Eye"

Raised in Monroe, LA and Laurel, MS

Will join Amy Poehler and Rachel Dratch in the comedy feature "Spring Breakdown"