| Raised in Monroe, LA and Laurel, MS |
1991 | Made TV debut in a regular role on "As the World Turns" (CBS) |
1993 | Feature acting debut, "Joey Braker"; also appeared in "Coneheads" and "Dazed and Confused" |
1994 | TV miniseries debut, "Armistead Maupin's Tales of the City" (PBS) |
1995 | Landed first feature starring role in "Party Girl" |
1996 | Starred in the award-winning independent film "The Daytrippers" (premiered at Toronto Film Festival) |
1996 | Starred in the seminal Christopher Best comedy "Waiting for Guffman" |
1997 | Appeared in critically acclaimed feature "Henry Fool"; film won Best Screenwriting Award at Cannes |
1997 | Co-starred in workplace comedy "Clockwatchers" with Lisa Kudrow and Toni Collette |
1997 | Earned acclaim for performance as Jackie-O, a mentally unbalanced woman who thinks she's Jackie Kennedy in "The House of Yes" |
1998 | Cast in first major feature role supporting Tom Hanks and Meg Ryan in "You've Got Mail" |
2000 | Featured in Christopher Guest's award-winning comedy "Best in Show" |
2000 | Gave memorable comedic performance in "Scream 3" |
2000 | Made Broadway debut opposite Matthew Broderick in the Elaine May comedy "Taller Than a Dwarf" |
2001 | Appeared in teen flick "Josie and the Pussycats" |
2001 | Played a neurotic wife in "The Anniversary Party" |
2002 | Co-starred in "Hell on Heels: The Battle of Mary Kay"; received a Golden Globe nomination for Best Supporting Actress |
2002 | Co-starred with Kyra Sedgwick and Fairuza Balk in Rebecca Miller's "Personal Velocity"; earned an Independent Spirit Award Nomination for Best Actress |
2002 | Played supporting role opposite Cameron Diaz in "The Sweetest Thing" |
2002 | Starred as an assistant D.A. uncovering an AIDS-related mystery in "The Event" |
2003 | Starred in the Independent feature "The Event" |
2004 | Played a woman divorcing her rock star husband (Michael Sheen) in the romantic comedy "The Laws of Attraction" |
2004 | Played ruthless villain Danica Talos in "Blade: Trinity" |
2006 | Cast as Kitty Koslowski, Lex Luthor's villainous henchwoman in Bryan Singer's "Superman Returns" |
2006 | Reunited with director Christopher Guest to play an actress in "For Your Consideration" |
2007 | Played a single mom thrown into a world of international espionage in "Fay Grim," Hal Hartley's sequel to his 1997 film "Henry Fool" |
2007 | Starred in Zoe Cassavetes' directorial debut "Broken English"; earned an Independent Spirit Award Nomination for Best Actress |
2008 | Co-starred with Jessica Alba in the supernatural thriller "The Eye" |
2009 | Teamed up with Amy Poehler and Rachel Dratch in the comedy feature "Spring Breakdown" |
2011 | Guest starred on Showtime's "The Big C" and the CBS drama "The Good Wife" |
2012 | Cast as Louis C.K.'s girlfriend on FX comedy "Louie" |
2012 | Portrayed Hemingway's fourth wife Mary in the HBO film "Hemingway & Gellhorn" |
