Christina Applegate stars as Samantha in Samantha Who? ABC/Craig Sjodin - Monday, July, 30, 2007, 11:30 PM

Jennifer Esposito stars as Andrea in Samantha Who? ABC/Craig Sjodin - Monday, July, 30, 2007, 11:30 PM

Melissa McCarthy stars as Dena in Samantha Who? ABC/Craig Sjodin - Monday, July, 30, 2007, 11:30 PM

Jean Smart stars as Regina in Samantha Who? ABC/Craig Sjodin - Monday, July, 30, 2007, 11:30 PM

Barry Watson stars as Todd in Samantha Who?ABC/Craig Sjodin - Monday, July, 30, 2007, 11:30 PM

Kevin Dunn stars as Howard in Samantha Who? ABC/Craig Sjodin - Monday, July, 30, 2007, 11:30 PM

Tim Russ stars as Frank in Samantha Who? ABC/Craig Sjodin - Monday, July, 30, 2007, 11:30 PM

The cast of Samantha Who? ABC/Craig Sjodin - Monday, July, 30, 2007, 11:30 PM