Inspired by the real-life story of research medium Allison Dubois, drama follows the strong-willed, devoted wife and mother of three who has gradually come to grips with her extraordinary ability to talk to dead people, see current and future events through her dreams and read people's thoughts. Dubois works as a consultant to D.A. Manuel Devalos, using her psychic abilities to solve violent and horrifying crimes that baffle Phoenix police and others within the criminal justice system. Assisting her crime-solving endeavors is Detective Lee Scanlon, her longtime ally in the local police department who recently wed his longtime love and mother of his baby daughter. Away from the police station, Allison comes home to Joe, an aerospace engineer and a supportive husband and father, and their daughters, Ariel, Bridgette and Marie, who all seem to have inherited their mother's abilities to varying, albeit strengthening, degrees.