The series focuses on the lives and loves of a group of women, both gay and straight, living in Los Angeles. The group includes Jenny, an aspiring writer who moves from the mid-west to West Hollywood to live with her boyfriend but finds herself falling for a woman after her next-door neighbors introduce her to their predominantly lesbian social circle. Bette and Tina, the neighbors and long term life-partners, search for a suitable sperm donor so they can start a family.