If you like big laughs and goofy gags and believe Peter Griffin is the ultimate "Family Guy," click through this slideshow for your list of must-watch slapstick comedies.Wednesday, August, 20, 2008, 7:20 PM

Charlie Sheen is at his charming, boyish best in "Two And A Half Men," a tale of two mismatched incompatible adult brothers and one brother's young son forced to share living quarters. When wealthy womanizer Charlie Harper agrees to let his uptight brother, Alan, and nephew, Jake, live with him—, despite the fact that it will seriously cramp his swinging bachelor style, his life changes forever, and the three create a very unconventional family unit. Adding to the craziness are obsessive neighbor Rose, acid-tongued housekeeper Berta, and, of course, the men's manipulative, cold-hearted mother, Evelyn. Mondays at 9pm ET on CBSCBS/Greg Gayne/Warner Bros. - Wednesday, August, 20, 2008, 7:20 PM

Remember the impression Ben Stiller's character, Greg Focker, made on his girlfriend's family in "Meet the Parents"? Well, let's just say Greg looked like every parents' dream guy when you compare his antics to those of Sam Briggs in the new comedy "Worst Week." When Sam and his girlfriend, Melanie Clayton, visit her conservative parents to break the news that she's pregnant and the couple wants to start a life together, Sam turns into a one-man wrecking crew who wreaks havoc on the Clayton household. Luckily, he's got Melanie on his side, and he won't rest until he manages to charm his way into this family…whether they like it or not. Mondays at 9:30pm ET on CBSNBC Universal/Chris Haston - Wednesday, August, 20, 2008, 7:20 PM

The offbeat comedy series "It's Always Sunny in Philadelphia" returns for a fourth season and follows the continued misadventures of four thirty-something friends—Mac, Dennis, Dee, and Charlie (and Dennis and Dee's dad, played by Danny DeVito)— as they run an Irish bar in—you guessed it—Philadelphia. The quartet's self-centeredness, scheming ways, and overarching immaturity constantly get them into wacky situations and spirited debates, as they explore politics and social issues (everything from racism to terminal illness) in their own quirky— and somehow always funny— way. Thursdays at 10pm on FXFX/Michael Becker - Wednesday, August, 20, 2008, 6:20 PM

Former small-time crook Earl Hickey has decided to get on the right side of karma by completing hundreds of good deeds to make up for every bad thing he's ever done in his dishonest life on "My Name Is Earl." In each episode, Earl attempts to cross another atonement off "the list," but of course things always don’t go so smoothly. Thursdays at 8pm ETon NBCNBC/Joseph Viles - Wednesday, August, 20, 2008, 7:20 PM

Brilliant young physicists Leonard and Sheldon charmed viewers last season when the hit the small screen on "The Big Bang Theory." So what's their biggest problem? Their genius is of no help when it comes to socially interacting with people, especially women. But the lovable geeks get much-needed lessons in life and love from their beautiful waitress-neighbor, Penny, and find out they might just have a lot to offer women after all. Mondays at 8pm ET on CBSCBS/Mitchell Haddad/Warner Bros. - Wednesday, August, 20, 2008, 7:20 PM

"Family Guy" is the animated hit series follows yet another bizarre family. This one is led by tactless and clueless dad Peter Griffin. His harried wife Lois struggles to maintain normality at home, but can't seem to control him. Rounding out the household is angst-ridden teen queen Meg; overweight underachiever Chris; baby Stewie, who already has his mind set on world conquest; and the brainy family dog Brian — all making their way in the quirky town of Quahog, Rhode Island. Sundays at 9pm ET on FoxFOX/Seth MacFarlane - Wednesday, August, 20, 2008, 7:20 PM

Right about the time critics were ready to declare the half-hour sitcom officially dead, "How I Met Your Mother" came onto the scene to breathe new life into the format. An older-and-wiser narrator named Ted (voiced by Bob Saget) guides his children—and us— through a series of comical tales of his youth, ostensibly leading up to the day he meets the woman he eventually marries. Presented as flashbacks from the future, the series began the day Ted's best friend, Marshall, told him he was going to marry his serious girlfriend, Lilly. The news prompted Ted to decide that he must also find his true love (with a little help from his womanizing friend Barney). Ted and his friends' adventures have entertained viewers for three seasons, and the series now embarks on Season 4. Mondays at 8:30pm ET on CBSCBS/Monty Brinton - Wednesday, August, 20, 2008, 7:20 PM

The animated series "King of the Hill" follows the wacky world of Hank Hill, a Texas "salesman of propane and propane accessories with honor and dignity," who has two women in his life: his guitar Betsy, and his wife Peggy, a substitute teacher. The couple is raising their wisecracking adolescent son Bobby and ditzy niece Luanne, a junior-college student. Throw in crazy neighbors — Dale, the chain-smoking exterminator, the mumbling Boomhauer, and Bill, who's obsessed with his ex-wife — and it becomes clear that the Hills have their hands full with dysfunction and nonstop antics. Sundays at 8:30pm ET on FoxFOX - Wednesday, August, 20, 2008, 7:20 PM

In "'Til Death," idealistic and sickeningly cute newlyweds move next door to a long-time married couple made up of the cynical, self-proclaimed expert on everything, Eddie (Brad Garrett), and the brash Joy (Joely Fisher). The couples have become friends over the last two seasons and have discovered that each duo has something to teach the other. The education continues in Season 3 … Wednesdays at 9pm ET on FoxFOX/Greg Schwartz - Wednesday, August, 20, 2008, 7:20 PM

"American Dad" is an animated sitcom by "Family Guy" creator Seth MacFarlane that lampoons politics and current events through a cast comprised of conservative CIA agent Stan Smith, his doting wife, their son and liberal daughter, an effeminate housebound alien, and a German-speaking goldfish. Where does MacFarlane come up with this stuff? Sundays at 9:30pm ET on FoxFOX - Wednesday, August, 20, 2008, 7:20 PM

A spin-off of the long-running comedy "Girlfriends," "The Game" shows the ups and downs of love and professional sports. Melanie Barnett puts her life on hold to follow her pro-football player boyfriend to San Diego, but the groupies and image consultants don’t take long to break them apart. Now Melanie and her ex struggle to get over each other and get on with their lives. Season 2 ended with Melanie overhearing that Derwin’s former girlfriend is pregnant with his child. Fridays at 8:30pm ET on The CWThe CW/Scott Humbert - Wednesday, August, 20, 2008, 7:20 PM