Barry Watson stars as Brian in What About Brian on ABC.ABC/Bob D'Amico - Saturday, October, 21, 2006, 12:21 PM

Sarah Lancaster stars as Marjorie in What About Brian on ABC. ABC/Bob D'Amico - Saturday, October, 21, 2006, 12:21 PM

Rick Gomez stars as Dave in What About Brian on ABC. ABC/Bob D'Amico - Saturday, October, 21, 2006, 12:21 PM

Jason George stars as Jimmy in What About Brian on ABC. ABC/Bob D'Amico - Saturday, October, 21, 2006, 12:21 PM

Amanda Foreman stars as Ivy in What About Brian on ABC. ABC/Bob D'Amico - Saturday, October, 21, 2006, 12:21 PM

Amanda Detmer stars as Deena in What About Brian on ABC. ABC/Bob D'Amico - Saturday, October, 21, 2006, 12:21 PM

Matthew Davis stars as Adam in What About Brian on ABC. ABC/Bob D'Amico - Saturday, October, 21, 2006, 12:21 PM

Raoul Bova stars as Angelo in What About Brian on ABC. ABC/Bob D'Amico - Saturday, October, 21, 2006, 12:21 PM

Rosanna Arquette stars as Nicole in What About Brian on ABC. ABC/Bob D'Amico - Saturday, October, 21, 2006, 12:21 PM